Creatine
3K 0 02/20/2019 (nyochagharị ikpeazụ: 02/28/2019)
Creatine phosphate (aha Bekee - creatine phosphate, usoro kemịkalụ - C4H10N3O5P) bụ ngwongwo ike dị elu nke etolitere n'oge mgbanwe phosphorylation nke creatine ma na-agbakọba (95%) na akwara na akwara.
Isi ọrụ ya bụ iji hụ na nkwụsi ike nke mmepụta nke ike intracellular site na ịnọgide na-enwe ọkwa dị mkpa nke adenosine triphosphoric acid (ATP) site na resynthesis.
Mmiri mmiri ọgwụ nke creatine phosphate
N'ime ahụ, sekọnd ọ bụla enwere ọtụtụ usoro biochemical na physiological nke chọrọ oriri ike: njikọ nke bekee, mbufe nke ụmụ irighiri ihe ndị na-emepụta ihe na microelements na akụkụ nke sel, arụmọrụ nke mgbatị ahụ. A na-emepụta ike achọrọ n'oge hydrolysis nke ATP, ihe omimi ọ bụla nke resynthesized karịa oge 2000 kwa ụbọchị. Ọ naghị agbakọta na anụ ahụ, na maka ịrụ ọrụ nke usoro sistemụ na akụkụ akụkụ niile ya, achọrọ njupụta oge ọ bụla nke itinye uche ya.
Maka ebumnuche ndị a, e zubere creatine phosphate. A na - emepụta ya mgbe niile ma bụrụkwa ihe bụ isi nke mmeghachi omume nke mbelata ATP site na ADP, nke enzyme pụrụ iche - creatine phosphokinase na - akpata. N'adịghị ka adenosine triphosphoric acid, mọzụlụ na-enweta ya oge niile.
N’ime mmadụ gbasiri ike, olu nke creatine phosphate ruru 1% nke ibu ahụ dum.
Na usoro nke creatine phosphatase, isoenzymes atọ nke creatine phosphokinase gụnyere: ụdị MM, MB na BB, nke dị iche na ọnọdụ ha: mmadụ abụọ mbụ bụ na ọkpụkpụ na akwara obi, nke atọ bụ na anụ ahụ nke ụbụrụ.
Resynthesis nke ATP
Ntughari nke ATP site na creatine phosphate bu ihe kachasi ike na ike nke uzo ato. Sekọnd abụọ nke arụ ọrụ ike dị n'okpuru nnukwu ọrụ zuru ezu, na resynthesis abanyelarị arụmọrụ ya kacha elu. N'okwu a, a na-emepụta ike ugboro 2-3 karịa oge glycolysis, CTA na phosphorylation oxidative.
Ule makaule - stock.adobe.com
Nke a bụ n'ihi ọnọdụ nke ndị na-emeghachi omume na nso nso mitochondria na ntinye ọrụ nke mmegharị site na ngwaahịa nke ikpochapụ ATP. Ya mere, mmụba siri ike na ike ọrụ ike adịghị eduga na mbelata nke ịta ahụhụ nke adenosine triphosphoric acid. N'ime usoro a, enwere oriri kpụ ọkụ n'ọnụ nke creatine phosphate, mgbe 5-10 sekọnd ọsọ ya na-amalite ibelata nkọ, na 30 sekọnd ọ na-agbada ruo ọkara nke oke uru. N'ọdịnihu, ụzọ ndị ọzọ nke ịgbanwe ogige macroenergy abata.
Normalzọ dị mma nke creatine phosphate bụ ihe dị mkpa maka ndị na-eme egwuregwu na-emetụta mgbanwe dị egwu na ngwongwo akwara (obere ọsọ ọsọ, ibuli elu, omume dịgasị iche iche na ibu, badminton, ịgba na ụdị egwuregwu ndị ọzọ na-agbawa agbawa).
Usoro nyocha nke nanị usoro a nwere ike inye nnukwu ego nke mmefu ume na nke mbụ nke ọrụ ahụ ike, mgbe ike nke ibu ahụ gbanwere ngwa ngwa na oke ike nrụpụta achọrọ n'oge pere mpe. A ga-eme ọzụzụ na egwuregwu ndị a dị n'elu site na ịtụle ntụpọ nke ozuzu zuru oke nke ahụ na isi iyi nke ike dị otú ahụ - creatine na "accumulator" nke agbụ macroenergetic - creatine phosphate.
Na izu ike ma ọ bụ na mbelata dị ukwuu nke ọrụ ahụ ike, oriri nke ATP na-ebelata. Ọnụọgụ nke oxidative resynthesis na-anọgide n'otu ọkwa ahụ ma "njupụta" nke adenosine triphosphoric acid ka eji weghachi ihe nchekwa nke creatine phosphate.
Mmekọrịta nke creatine na creatine phosphate
Akụ ndị bụ isi na-emepụta creatine bụ akụrụ na umeji. Usoro a na-amalite na akụrụ site na ịmepụta guanidine acetate site na arginine na glycine. Ekem, a na-emepụta creatine n'ime imeju site na nnu a na methionine. Site na nrughari ọbara, a na-ebuga ya na ụbụrụ na akwara ahụ, ebe a gbanwere ya n'ime creatine phosphate n'okpuru ọnọdụ kwesịrị ekwesị (enweghị ma ọ bụ obere ọrụ ike na ọnụ ọgụgụ zuru ezu nke mkpụrụ ndụ ATP).
Nlekọta ahụike
N’anụ ahụ ike, akụkụ nke creatine phosphate (ihe dịka 3%) na-agbanwe mgbe niile ka ọ bụrụ creatinine n’ihi nsonaazụ enzymatic dephosphorylation. Ego a agbanweghi, ma kpebisiri ike site na olu nke akwara. Dị ka ihe ekwupụtaghị, ọ na-ewepụ ya na mmamịrị kpamkpam.
Iji chọpụta ọnọdụ nke akụrụ, nyocha nke kwa ụbọchị nke creatinine na-enye ohere. Obere itinye uche n’ime ọbara nwere ike igosipụta nsogbu akwara, na ịkarị oke iwu na-egosi ọrịa akụrụ nwere ike.
Ngbanwe nke ogo creatine kinase n’ime ọbara na-eme ka o kwe omume ịmata mgbaàmà nke ọtụtụ ọrịa obi (myocardial infarction, hypertension) na ọnụnọ nke mgbanwe ngbanwe ahụ na ụbụrụ.
Site na atrophy ma ọ bụ ọrịa nke sistemu akwara, ihe okike anaghị emepụta na anụ ahụ ma wepụ ya na mmamịrị. Nchịkọta ya na-adabere n'ịdị njọ nke ọrịa ma ọ bụ ogo nha nke arụmọrụ ahụ.
Creatseụbiga mmanya ókè nke creatine nwere ike ibute ọdịnaya ọdịnaya nke creatine na mmamịrị n'ihi enweghị idebe iwu nke ntuziaka maka iji mgbakwunye egwuregwu.
