Ndị na-edozi ahụ bụ ihe kachasị mkpa dị na ahụ mmadụ, ha na-etinye aka na njikọ nke homonụ na enzymes, ha dị mkpa maka mmejuputa oke ọnụọgụ nke mmeghachi omume biochemical. A na-ewu mkpụrụ ndụ protein dị mgbagwoju anya site na amino acid.
Leucine bụ otu n'ime ihe kachasị mkpa na otu a. Na-ezo aka amino acid dị mkpa nke ahụ na-enweghị ike ịkọpụta n'onwe ya, mana na-enweta site n'èzí. A na-eji Leucine mee ihe na egwuregwu na-edozi ahụ, ọgwụ, na ọrụ ugbo. Na ụlọ ọrụ nri, a maara ya dị ka mgbakwunye E641 L-Leucine ma jiri ya gbanwee uto na isi nri.
Nnyocha amino acid
Na nke mbụ, leucine dịpụrụ adịpụ yana onye nhazi ọgwụ kọwara Henri Braconneau na 1820. Ná mmalite nke narị afọ nke 20, Hermann Emil Fischer nwere ike iji aka ya mepụta ụlọ ọrụ a. Na 2007, akwụkwọ akụkọ ọrịa shuga bipụtara nsonaazụ nke ọmụmụ sayensị banyere ọrụ na akụrụngwa nke leucine. Nwere ike ịlele nsonaazụ na nkwubi okwu nke ndị ọkà mmụta sayensị site na njikọ (ozi dị na Bekee).
Emere nnwale ahụ na oke ụmụ nyocha. E kere anụmanụ ndị ahụ ụzọ abụọ. Na nke mbụ n'ime ha, òké ahụ na-enweta nri oge niile, na nri nke abụọ, enwere oke nri abụba. N’akụkụ nke ọzọ, e kere ìgwè ọ bụla n’ime ìgwè abụọ: n’ime otu n’ime ha, a na-enye ụmụ anụmanụ 55 mg nke leucine kwa ụbọchị, na nke abụọ, ụmụ oke ahụ enwetaghị ogige ndị ọzọ na mgbakwunye na nri a chọrọ.
Site na nsonaazụ nke izu iri na ise, ọ bịara bụrụ na anụmanụ ndị e nyere nri mara abụba nwere ibu. Agbanyeghị, ndị natara leucine ọzọ nwetara 25% pere mpe karịa ndị na-anataghị amino acid na nri ha.
Na mgbakwunye, nyocha ndị ahụ gosiri na ụmụ anụmanụ na-a leụ leucine riri oxygen karịa ndị ọzọ. Nke a pụtara na usoro ọgwụgwọ ha na-eme ngwa ngwa, na-agbanyekwu calorie. Eziokwu a egosila ndị sayensị na amino acid na-ebelata usoro nke abụba anụ ahụ.
Nnyocha ọmụmụ ụlọ nyocha nke akwara akwara na adipocytes dị ọcha anụ ahụ gosipụtara na ịmịnye ọgwụ ọzọ nke leucine na ahụ na-akpali mmepụta nke mkpụrụ ndụ ihe na-enyeghị aka na protein, nke na-akpali abụba kpụ ọkụ n'ọnụ karịa na cellular larịị.
Na 2009, ndị ọkà mmụta sayensị na Mahadum Pennsylvania kwughachiri nnwale nke ndị ọrụ ibe ha. Enwere ike ịchọta nsonaazụ nke ọmụmụ a ebe a (a na-enyekwa ozi n'asụsụ Bekee). A chọpụtawo nkwubi okwu nke ndị ọkà mmụta sayensị. Achọpụtakwara na ịwe obere amino acid enweghị mmetụta na oke.
Ọrụ ndu nke leucine
Leucine na-arụ ọrụ dị mkpa n'ọtụtụ usoro. Ọ na-arụ ọrụ ndị a:
- na-ebelata usoro catabolic na akwara;
- na-eme ka njikọ nke protein molecules dị ngwa, nke na-enyere aka iwulite akwara;
- lowers ọbara shuga;
- na-enye nguzo nke nitrogen na nitrogenous ogige, nke dị mkpa maka protein na carbohydrate metabolism;
- na-egbochi njikọta oke nke serotonin, nke na - enyere aka belata ike ọgwụgwụ ma mee ngwangwa mgbake na nrụgide.
Ihe odide nke leucine dị n’ọbara na-ewusi usoro ahụ ji alụso ọrịa ọgụ, na-akwalite ọgwụgwọ ọnya, ma na-eme ka mgbake sitere na mmerụ ahụ ngwa ngwa. Ahụ na-eji ya dị ka isi iyi nke ike.
Ngwa na egwuregwu
Site na arụ ọrụ siri ike, ahụ chọrọ ihe ndị ọzọ iji wuo akwara ma wepụ ume. N’egwuregwu, ọkachasị ọzụzụ ike dị ka iwuli ahụ mmadụ elu, iwuli elu, ịga ije, leucine bụ omume a na-ahụkarị.
Ọ dị mkpa iji belata ike nke catabolism na ngwa ngwa usoro anabolic. Dịka, a na-ewere amino acid n'ụdị mgbakwụnye egwuregwu nke nwere mgbagwoju BCAA. O nwere amino acid ato di mkpa - leucine, isoleucine na valine.
N'ime ihe mgbakwunye nri ndị dị otú ahụ, nha nke ihe ndị mejupụtara bụ 2: 1: 1 (n'otu n'otu, leucine, isomer na valine ya), ụfọdụ ndị nrụpụta na-abawanye ọdịnaya nke mbụ site na abụọ ma ọ bụ ugboro anọ.
Nke a na-eji amino acid eme egwuregwu maka ike anụ ahụ na oke ibu. Na mgbakwunye, mgbakwunye leucine na-eme ka ikike dị mkpa iji meziwanye egwuregwu.
Ngwa na ọgwụ
A na-ejikwa ọgwụ ndị nwere ọgwụ Leucine maka ọgwụgwọ. Edere ha maka ọrịa imeju siri ike, dystrophy, poliomyelitis, neuritis, anaemia, na ụfọdụ nsogbu ahụike ọgụgụ isi.
Dị ka a na-achị, a na-etinye nlekọta nke onyinye a na ọgwụ ndị nwere glutamic acid na amino acid ndị ọzọ iji welie mmetụta ọgwụgwọ.
Uru nke leucine maka ahụ gụnyere mmetụta ndị a:
- normalization nke ọrụ hepatocyte;
- na-ewusi ọgụ;
- mbenata ihe ize ndụ nke oke ibu;
- nkwado maka ezigbo uru ahụ;
- osooso nke mgbake mgbe mgbatị ahụ, ịbawanye arụmọrụ;
- mmetụta bara uru na ọnọdụ akpụkpọ.
A na-eji amino acid eme ihe maka mgbake nke ndị ọrịa na-ata ahụhụ site na dystrophy, edepụtara ya mgbe ebu ọnụ dị ogologo. A na-ejikwa ya n'ọgwụgwọ ndị ọrịa kansa na ndị ọrịa nwere imeju imeju. A na-eji ha eme ngwangwa mgbake site na mmerụ ahụ, ịwa ahụ, yana yana mmemme ịka nká.
Daily chọrọ
Mkpa maka okenye bụ 4-6 g nke leucine kwa ụbọchị. Ndị na-eme egwuregwu chọrọ ntakịrị karịa nke ogige a.
- Ọ bụrụ na ebumnuche bụ iwulite akwara, mgbe ahụ ọ na-atụ aro ka ị were 5-10 g n'oge na mgbe ọzụzụ. Usoro a na-ejide ogo leucine zuru oke n'ime ọbara n'oge mmega ahụ siri ike, nke na-eme ka akwara eriri ahụ ike.
- Ọ bụrụ na ebumnuche nke onye na-eme egwuregwu bụ ọnwụ, mbido, mgbe ahụ ịkwesịrị iji ihe mgbakwunye nwere leucine 2-4 ugboro n'ụbọchị, n'ihe ruru 15 g. A na-ewere mgbakwunye ahụ n'oge na mgbe ọzụzụ, yana kwa 1-2 ugboro n'ụbọchị n'etiti nri. Atụmatụ a na-akpali metabolism ma na-akwalite abụba ọkụ. N'otu oge ahụ, a na-echekwa akwara, ma na-egbochi usoro catabolic.
Gafere ụkpụrụ nwere ike ibute oke leucine n'ime ahụ ma bụrụ ihe na-emerụ ahụ ike. Ọ bụ ihe amamihe dị na ya ịkpọtụrụ onye dibịa tupu iji ọgwụ ọ bụla ma ọ bụ mgbakwunye nri nwere amino acid a. Ndị na-agba ọsọ nwere ike ịdabere na onye nkuzi ọkachamara nwere ahụmịhe iji chọta usoro ọgwụgwọ kwesịrị ekwesị.
Nsonaazụ nke ụkọ na ngafe na ahụ nke leucine
Leucine bụ amino acid dị mkpa: ya mere, ọ dị oke mkpa ịnweta ngwakọta ngwakọta a site na mpụga. Enweghị ya n'ahụ na-eduga n'ọdịdị nitrogen na-adịghị mma ma na-agbagha usoro usoro metabolism.
Ọrịa Leucine na-akpata uto ụmụaka na-eto eto n'ihi erughị oke mmepụta hormone. Ọzọkwa, enweghi amino acid a na-akpali mmepe nke hypoglycemia. Mgbanwe usoro ọgwụgwọ na-amalite na akụrụ, thyroid gland.
Leụbiga leucine nwekwara ike iduga n'ọtụtụ nsogbu. Nribiga oke amino acid a na - enyere aka na mmepe onodu onodu onodu onodu aru ike:
- nsogbu akwara ozi;
- na-ekwu hoo haa;
- isi ọwụwa;
- hypoglycemia;
- mmepe nke mmeghachi omume immunological na-adịghị mma;
- atrophy anụ ahụ.
Isi mmalite nri nke Leucine
Ahụ na - enweta amino acid a naanị site na nri ma ọ bụ mgbakwunye na ọgwụ pụrụ iche - ọ dị mkpa iji hụ na ọkọnọ nke onyinye a zuru oke.
Otu n'ime mgbakwunye ọgwụ leucine
Iji mee nke a, a na-atụ aro ka ị jiri ngwaahịa ndị a:
- mkpụrụ;
- soy;
- peas, legumes, ahụekere;
- chiiz (cheddar, parmesan, Switzerland, poshekhonsky);
- ngwaahịa mmiri ara ehi na mmiri ara ehi dum;
- toro toro;
- acha uhie uhie;
- azụ (azụ asa, salmọn pink, mmiri bass, makarel, pike perch, pike, cod, pollock);
- anụ ụlọ na imeju anụ ezi;
- ọkụkọ;
- nwa Atụrụ;
- akwa ọkụkọ;
- ọka (millet, ọka, osikapa agba aja aja);
- sesame;
- skwid;
- akwa ntụ ntụ.
A na-ahụ leucine na protein na mgbatị dị iche iche nke ndị egwuregwu na-eme.
Nkwekọrịta
Omfọdụ anomali ndị a na-adịghị eketa eketa bụ ihe na-egbochi ị toụ leucine.
- Leucinosis (ọrịa Menkes) bụ nkwarụ metabolic nke amino acid hydrophobic (leucine, isoleucine na valine). A chọpụtara ọrịa a ugbua n’ụbọchị mbụ nke ndụ. Ọrịa ahụ chọrọ nhọpụta nke nri pụrụ iche, site na nke ewepu nri protein. A na-eji protein hydrolysates dochie ya, nke na-enweghị mgbagwoju BCAA amino acid. Ihe omuma a nke leucinosis bu isi nke mmamiri, nke na-esi isi nke okpukpo oku ma obu syrup maple.
- Ọrịa ọzọ kpebisiri ike na mkpụrụ ndụ ihe nketa, isovaleratacidemia, na-enye ihe osise nke ihe yiri ọrịa Menkes. Nke a bụ nsogbu dịpụrụ adịpụ nke leucine metabolism, bụ nke a ga-ewepụkwa nri amino acid n'ime ahụ.
Ọtụtụ mmeghachi omume biochemical n'ime ahụ agaghị ekwe omume na-enweghị leucine. Enwere ike inweta ya site na ngwaahịa nri na ego achọrọ naanị site na nri kwesịrị ekwesị, agbanyeghị, site na mgbasi ahụ ike, oriri amino acid na-abawanye nke ukwuu.
Inweta leucine dị mkpa maka ndị na-eme egwuregwu na-achọ imezi ụlọ ahụ ike site na ibelata usoro nke usoro catabolic. Inweta amino acid ga - enyere gi aka idalata mgbe ina - eme ka akwara ghara agbanwe.
